I am Lyra
Harmony in Evidence
The medical research agent in the DNAi Healthcare Fleet. Lyra conducts systematic literature search, evidence synthesis, meta-analysis support, clinical-trial review, and research gap identification across a dedicated biomedical research corpus.
Try Lyra via API Get an API keyAPI-only access · Inherits Asha's Sacred Refusals · Citation-precise
What Lyra Does
Lyra is the research librarian who knows every paper and every limitation. She is built for the questions a methodical evidence reviewer asks.
Systematic literature search
PICO-framed queries (Population, Intervention, Comparison, Outcome) across PubMed, OpenAlex, PMC full text, StatPearls, and clinical guidelines.
Evidence synthesis
Multi-collection retrieval combined into a coherent summary with quality grading and explicit confidence assessment.
Meta-analysis support
Heterogeneity assessment, publication-bias flags, and statistical aggregation cues for downstream review software.
Clinical trial review
Trial-design evaluation, outcome interpretation, and risk-of-bias assessment using Oxford CEBM evidence levels.
Research gap identification
What the corpus does not contain. Where evidence is thin, where trials contradict, where the next study is needed.
Citation verification
Confirms PMIDs and DOIs exist and match the claim. Lyra cannot fabricate references; that is an architectural constraint inherited from Asha.
How Lyra Is Grounded
Lyra runs in platform mode with research-weighted boosts defined in agents/lyra/agent.yaml. The corpus is the same fleet-wide store of roughly 829 live collections and over 126 million vectors.
| Collection | Boost | Scale | What it carries |
|---|---|---|---|
pubmed_abstracts |
1.5x | 5.1M abstracts | Biomedical abstract corpus, the backbone of any review |
openalex_top_cited |
1.4x | 16.5M works | Citation-weighted top research across disciplines |
pmc_fulltext_cited |
1.4x | 5.2M articles | Open-access full text from PubMed Central |
statpearls_clinical |
1.3x | 76K articles | Peer-reviewed clinical reference |
pkg2_cited_structured |
1.3x | 13.1M records | Structured citation graph for forward and backward tracing |
pkg2_keywords |
1.2x | 7M records | Keyword-indexed research for precise term filtering |
clinical_guidelines |
1.2x | varies | Specialty-society practice guidelines |
Sample Queries
Lyra is built for the questions a senior reviewer would frame. Below are representative shapes; cited evidence is returned with collection name and PMID when available.
Comparative effectiveness
"Compare GLP-1 receptor agonists and dual GIP/GLP-1 agonists for type 2 diabetes weight outcomes. Grade evidence."
Lyra retrieves head-to-head trials from pubmed_abstracts and pmc_fulltext_cited, scores study quality, and reports a confidence rating with explicit citations.
Systematic-review scoping
"Scope a systematic review on omega-3 supplementation for unipolar depression. Note heterogeneity."
Returns PICO frame, inclusion criteria, candidate trials from openalex_top_cited, and a heterogeneity flag where effect sizes diverge.
Trial-design critique
"Risk-of-bias assessment for a recent atrial-fibrillation pulsed-field ablation trial."
Pulls from statpearls_clinical and clinical_guidelines, applies CEBM grading, and flags blinding, randomization, and outcome-ascertainment concerns.
Research gap analysis
"What is the evidence gap on long-COVID neurocognitive sequelae in adolescents?"
Returns existing coverage with confidence ratings plus an explicit list of what the corpus does not answer. Useful for grant scoping and methods sections.
API Access
Lyra is available exclusively through the DNAi A2A protocol. There is no consumer chat surface; Lyra runs underneath Asha and is reachable to external researchers via API key.
POST /a2a/v1/message:send with agent_id: lyra. Free tier includes 50 queries per month; Developer, Pro, and Enterprise tiers scale to unlimited.
Standard endpoint
POST https://api.askasha.org/a2a/v1/message:send with bearer token. Specify agent_id: lyra in the message payload.
Task lifecycle
Async tasks accessible via GET /a2a/v1/tasks/{id}. Cancel in-flight work with POST /a2a/v1/tasks/{id}:cancel.
Discovery card
Lyra's agent card lives at /.well-known/agent-card.json with epistemic metadata, capabilities, and rate limits.